Correction: ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

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This article was republished on November 10, 2014, to correct errors in the online version only. The two affiliations for the second author, Bridget M. Barker, were omitted. These are now correct in the online version and are the following: Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, United States of America Current address: Pathogen Genomics Division, Translational Genomics Institute and Northern Arizona University, Flagstaff, Arizona, United States of America There was no correction necessary to the PDF version.

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ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

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RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus

SREBP transcription factors play a critical role in fungal virulence; however, the mechanisms of sterol regulatory element binding protein (SREBP) activation in pathogenic fungi remains ill-defined. Screening of the Neurospora crassa whole-genome deletion collection for genes involved in hypoxia responses identified a gene for an uncharacterized rhomboid protease homolog, rbdB, required for gro...

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At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogen and host cells must survive. Currently, whether hypoxia adaptation is an important virulence attribute of opportunistic pathogenic molds is unknown. Here we report the characterization of a sterol-r...

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2014